602 papers
This study demonstrates that Presenilin 1 (PS1) resides in the mitochondrial inner membrane where it regulates cristae junction protein arrangement and cristae formation by preventing ATAD3A oligomerization, thereby maintaining mitochondrial function and preventing dysfunctions associated with Alzheimer's disease.
This study reveals that the continuous degradation of a stem-cell-related translational repression machinery by the Non-stop/dUbcH8/CTLH ubiquitin network safeguards enterocyte identity in young Drosophila, a process that fails during aging due to declining Non-stop levels and Rogue-mediated clearance of the machinery, leading to the reactivation of stem-cell programs and loss of cell identity.
Fasting enhances small intestinal regeneration after radiation-induced damage by enriching the gut bacterium *Akkermansia muciniphila*, which produces propionate to drive epigenetic histone acetylation that primes plastic persister stem cells for rapid tissue repair.
This study reveals that neuronal differentiation involves a dynamic rewiring of organelle communication networks, where early mitochondrial hubs transition to ER-peroxisome contacts that drive ether lipid biosynthesis and are essential for synaptic maturation and neuronal activity.
This study establishes the CondenScreen platform to systematically identify chemical and genetic modulators of aberrant biomolecular condensates, revealing their links to neurological disorders like DYT1 dystonia and microcephaly while validating a scalable approach for condensate-targeted drug discovery.
This study elucidates a stepwise mechanism for ULK1 complex recruitment to autophagic membranes, revealing how the ATG13:ATG101 dimer cooperates with WIPI proteins to insert a membrane-binding finger and how a ULK1 PVP motif docks to the complex to position the kinase domain for substrate phosphorylation and autophagy initiation.
This study reveals that ER stress-induced beta-cell apoptosis in Type 1 diabetes is driven by a novel positive feedback loop where proinflammatory lipid signaling products of iPLA2β enhance the transcriptional association of iPLA2β with NFκB and STAT1, thereby amplifying the expression of genes that promote cell death.
This study reveals that in oral lichen planus, chronic inflammation activates normally quiescent human oral epithelial stem cells, causing them to proliferate and adopt an aberrant differentiation program as a protective mechanism against ulceration.
This study utilizes ultrastructure expansion microscopy and complementary techniques to resolve the previously controversial localization, membrane topology, and dynamic redistribution of the testis-specific protein SUN5 during mammalian spermiogenesis, establishing a refined structural model for its essential role in head-tail coupling.
This study demonstrates that human iPSC-derived cortical organoids effectively model the delayed, multifactorial mechanisms of radiation-induced neural injury and recovery, serving as a scalable platform to identify and validate candidate mitigators like NSPP and amisulpride that attenuate structural and transcriptional damage.
Depletion of the nucleoporin NPP-3/NUP205 in *C. elegans* embryos triggers a spindle assembly checkpoint-mediated relocalization of prophase chromosomes to the nuclear periphery, a protective mechanism involving inner kinetochore proteins and BAF-1/LEM-2 that safeguards genomic integrity against nuclear envelope rupture-induced DNA damage.
This study reveals that in *C. elegans*, the conserved kinase UNC-51 phosphorylates the adaptor UNC-76 to trigger RAB-10-dependent retrograde trafficking of innexin proteins, thereby eliminating transient electrical synapses that are essential for early calcium dynamics and subsequent chemical synapse formation.
This study reveals that K-Ras4B localizes to the primary cilium via the chaperone PDE6D to sustain ciliation and regulate asymmetric cell divisions during skeletal muscle differentiation and heart development, thereby providing a mechanistic link between RASopathies and ciliopathies.
This study reveals that the Wnt signaling pathway regulates the timing of cell abscission in mouse embryonic stem cells through two distinct mechanisms involving Aurora B stability and GSK-3β-mediated microtubule dynamics, demonstrating that the pathway's impact on cell division is context-dependent and influenced by the cell's pluripotent state.
This study identifies GAPsec as a novel Rab5-GTPase activating protein essential for coordinating Rab5 and Rab7 regulation via the Bulli-Mon1-Ccz1 complex to ensure proper endosomal maturation and lysosomal degradation in fruit fly nephrocytes.
This study reveals that Influenza A virus enhances its replication by establishing a positive feedback loop where infection-induced c-Fos stabilizes the viral M2 protein, thereby preventing its degradation and promoting autophagosome accumulation to facilitate viral production.
This study reveals that early erythroid differentiation is characterized by a surprising, transitory strengthening of GATA2 chromatin engagement, where the transcription factor exhibits increased residence time and selectively occupies distinct promoter- and enhancer-associated regulatory elements before being silenced as GATA1 levels rise.
This study utilizes a phenotypic screen of an FDA-approved drug library to identify diverse repurposable agents, including antidepressants and antimicrobials, that selectively block NLRP3 inflammasome priming or assembly and demonstrate protective effects against sepsis in a sex-dependent manner.
This study reveals that immune cells infected with the oversized parasite *Toxoplasma gondii* overcome migration bottlenecks by activating a size-dependent mechanoadaptive response involving intracellular repositioning, myosin-II contractility, and bleb-based protrusions to transport rigid cargo through confined spaces.
This study reveals that the mitochondrial E3 ligase MAPL restrains basal mitophagy by promoting non-canonical SUMO-2/3 modification of PINK1, thereby establishing a novel regulatory checkpoint for mitochondrial quality control.